SCIAN EVL SpherSIM

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SCIAN EVL SpherSIM — Help

Getting Started

1. Click Init to create the embryo sphere and place DFC cells.
2. Click Play to start the simulation. Cells will migrate driven by the EVL margin.
3. Use Pause to stop and Step to advance one frame at a time.
4. Rotate the 3D view by clicking and dragging in the viewport.

What Are DFC Cells?

Dorsal Forerunner Cells (DFCs) are a group of non-involuting cells in the zebrafish embryo that migrate collectively toward the vegetal pole, driven by the advancing Enveloping Layer (EVL) margin. They eventually coalesce to form Kupffer's vesicle, the organ of left-right asymmetry.

Simulation Parameters

• Embryo Radius: Size of the spherical embryo in spatial units.
• Number of DFCs: How many cells to place on the sphere.
• Cell Radial Size: Angular half-width of each cell (radians).
• Contour Vertices: Resolution of the cell boundary polygon.
• EVL Speed: Velocity of the EVL epiboly margin (radians/step).
• Noise Std: Amplitude of stochastic migration noise.
• Step Interval: Milliseconds between simulation frames.

3D View Controls

• Left-click + drag: Orbit (rotate) the view around the embryo.
• Scroll wheel: Zoom in and out.
• Right-click + drag: Pan the camera.